منابع مشابه
Multimodality Imaging of Tumor Angiogenesis: Perfusion Modeling for Tumor Angiogenesis
When a tracer, such as Gd-doped or iodinated extracellular contrast, is introduced into the blood stream of a patient its transport through the vascular system, heart and lungs and eventual excretion via the kidneys is a well-established process [1,2]. At the level of the imaging voxel (for example, in the centre of a breast tumor) we can only speculate as to the precise nature of the tracer ki...
متن کاملMolecular Imaging of Tumor Angiogenesis
Molecular imaging has recently been defined by the Society of Nuclear Medicine as ‘the visualization, characterization, and measurement of biological processes at the molecular and cellular levels in humans and other living systems’ (Mankoff 2007). It usually exploits specific labeled molecular probes, as well as intrinsic tissue characteristics as the source of image contrast, and uses a numbe...
متن کاملRadionuclide imaging of tumor angiogenesis.
Angiogenesis is a multistep process regulated by pro- and antiangiogenic factors. In order to grow and metastasize, tumors need a constant supply of oxygen and nutrients. For growth beyond 1-2 mm in size, tumors are dependent on angiogenesis. Inhibition of angiogenesis is a new cancer treatment strategy that is now widely investigated clinically. Researchers have begun to search for objective m...
متن کاملImaging Key Biomarkers of Tumor Angiogenesis
Angiogenesis is a fundamental requirement for tumor growth and therefore it is a primary target for anti-cancer therapy. Molecular imaging of angiogenesis may provide novel opportunities for early diagnostic and for image-guided optimization and management of therapeutic regimens. Here we reviewed the advances in targeted imaging of key biomarkers of tumor angiogenesis, integrins and receptors ...
متن کاملMultimodality molecular imaging of tumor angiogenesis.
Molecular imaging is a key component of 21st-century cancer management. The vascular endothelial growth factor (VEGF)/VEGF receptor signaling pathway and integrin alpha v beta 3, a cell adhesion molecule, play pivotal roles in regulating tumor angiogenesis, the growth of new blood vessels. This review summarizes the current status of tumor angiogenesis imaging with SPECT, PET, molecular MRI, ta...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2006
ISSN: 0021-9738
DOI: 10.1172/jci30058